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Horus Oncologist

Personalized prediction of therapeutic response in pancreatic cancer using AI

The Horus Oncologist project applies Machine Learning (ML) and Artificial Intelligence (AI) techniques to develop predictive models of therapeutic response in patients with non-metastatic pancreatic adenocarcinoma treated with stereotactic body radiation therapy (SBRT) in neoadjuvant phase. Through the analysis of clinical, diagnostic and radiological data, the aim is to predict the probability of surgical resection and the pathological response to treatment.

Problems to solve

The treatment of locally advanced pancreatic adenocarcinoma presents major clinical challenges. The lack of objective predictive tools hinders therapeutic planning and medical decision making. The ability to anticipate treatment response can significantly improve the selection of patients who are candidates for surgery and optimize available clinical resources.Horus Oncologist addresses this challenge by developing predictive models that combine clinical, radiological and dosimetric information, bringing value to precision medicine.

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Main features

  • Analysis of clinical and diagnostic variables: It studies the relationship between clinical-diagnostic data and treatment results (surgical resection and pathologic response).
  • Advanced radiomics: Extracts relevant features from computed tomography studies prior to SBRT to enrich the predictive model.
  • Integrated dosimetric data: Includes information on the dose administered to assess its influence on the therapeutic response.
  • Customized AI and ML models: Developed in R and Python, tailored to patient-specific data.
  • Medical decision support: Provides an objective tool for planning personalized treatments.
  • Applicability to other studies: Possibility of extrapolating the model to other tumor sites or therapeutic protocols.
  • Precision medicine: Contributes to the individualization of treatment in radiation oncology.
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